tag:blogger.com,1999:blog-6011966735431330184.post4668257016489910564..comments2023-10-17T22:37:35.235+07:00Comments on Clinical genetics, Medical genetics and molecular genetics: My project (7)Dr Prasit Phowthongkumhttp://www.blogger.com/profile/12398709883713733111noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-6011966735431330184.post-51367970858020193532007-11-19T01:13:00.000+07:002007-11-19T01:13:00.000+07:00The need to provide Cu to essential enzymes withou...The need to provide Cu to essential enzymes without ensuing cellular toxicity has necessitated evolution of tightly regulated Cu homeostatic mechanisms.Dr Prasit Phowthongkumhttps://www.blogger.com/profile/12398709883713733111noreply@blogger.comtag:blogger.com,1999:blog-6011966735431330184.post-78085493609982052662007-11-19T01:10:00.000+07:002007-11-19T01:10:00.000+07:00Copper can also bind with high affinity to histidi...<B>Copper can also bind with high affinity to histidine, cysteine and methionine residues of proteins which can result in their inactivation.</B>Dr Prasit Phowthongkumhttps://www.blogger.com/profile/12398709883713733111noreply@blogger.comtag:blogger.com,1999:blog-6011966735431330184.post-48363216436031909642007-11-19T01:08:00.000+07:002007-11-19T01:08:00.000+07:00The Cu(II) Cu (I) transitions can in certain circ...<I>The Cu(II) <--> Cu (I) transitions can in certain circumstances also result in the generation of reactive oxygen species, e.g. superoxide radical and hydroxyl radical, which, if not detoxified efficiently, can damage susceptible cellular components.</I>Dr Prasit Phowthongkumhttps://www.blogger.com/profile/12398709883713733111noreply@blogger.comtag:blogger.com,1999:blog-6011966735431330184.post-90969266804193149892007-11-19T01:04:00.000+07:002007-11-19T01:04:00.000+07:00THE ABILITY OF Cu TO CYCLE BETWEEN A STABLE OXIDIS...THE ABILITY OF Cu TO CYCLE BETWEEN A STABLE OXIDISED, Cu (II), AND UNSTABLE REDUCED, Cu(I), STATES IS USED BY CUPROENZYMES INVOLVED IN REDOX REACTIONS, E.G. Cu/Zn SUPEROXIDE DISMUTASE AND CYTOCHROME OXIDASE.Dr Prasit Phowthongkumhttps://www.blogger.com/profile/12398709883713733111noreply@blogger.com